The aim of this paper is to analyze the empirical evidence on ACT in the psychological treatment of cancer patients. Eight articles have been selected for the review, of which we were interested in those of experimental or quasi-experimental type in adult patients diagnosed with cancer and their relatives. The results, although heterogeneous, suggest medium- to long-term improvements after ACT intervention in the symptomatology of anxiety, depression, acceptance, quality of life, stress and psychological flexibility. In addition, ACT has been found to be more effective compared to other psychological therapies. Thus, despite the limitations found in this study, promising results have been obtained for future reviews and/or meta-analyses.